Why is it so difficult to develop a hepatitis C virus preventive vaccine?
نویسندگان
چکیده
منابع مشابه
Why is ALS so Difficult to Treat?
Amyotrophic lateral sclerosis (ALS) is proving intractable. Difficulties in pre-clinical studies contribute in small measure to this futility, but the chief reason for failure is an inadequate understanding of disease pathogenesis. Many acquired and inherited processes have been advanced as potential causes of ALS but, while they may predispose to disease, it seems increasingly likely that none...
متن کاملChallenges for Brain Emulation: Why is it so Difficult?
In recent years, half a dozen major research groups have simulated or constructed sizeable networks of artificial neurons, with the ultimate goal to emulate the entire human brain. At this point, these projects are a long way from that goal: they typically simulate thousands of mammalian neurons, versus tens of billions in the human cortex, with less dense connectivity as well as lesscomplex ne...
متن کاملTB vaccine development: where are we and why is it so difficult?
The development of an effective TB vaccine remains paramount to achieving the goal of global eradication of TB by 2050. The only licensed vaccine, BCG, has variable efficacy and is poorly effective in high burden countries. The development of promising candidate vaccines to either 'boost' a BCG primed immune system or replace BCG altogether is a key area for innovative research. Here, we discus...
متن کاملHepatitis C Virus and Vaccine Development
The prevalence of Hepatitis C virus (HCV) is approximately 3% around the world. This virus causes chronic hepatitis, liver cirrhosis and hepatocellular carcinoma. The effectiveness of interferon-α and ribavirin therapy is about 50% and is associated with significant toxicity and cost. Hence, generating new vaccines or drugs is an obligation. However, there is no vaccine available for clinical u...
متن کاملReview: Patient safety: a core value of nursing – so why is achieving it so difficult?
Issues of patient safety have had greatest effect when responding to failures in safety or poor performance at particular hospitals or by particular individuals. Florence Nightingale was no different. Her understanding about what we now term as patient safety grew out of her own experiences of adverse events in healthcare. She learned from those patients that died unnecessarily and she learned ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Clinical Microbiology and Infection
سال: 2014
ISSN: 1198-743X
DOI: 10.1111/1469-0691.12493